Structure of PDB 5e7j Chain A

Receptor sequence
>5e7jA (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
EDDWSKPLPPSERLEQELFSGGIPVEATGNNCPPHIESFSDVEMGEIIMG
NIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIY
SDGPGEALRAMKKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVY
GGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADR
MLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYI
FLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETK
KGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVA
ARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNIN
ITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSS
3D structure
PDB5e7j Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A Y200 T204 Q207 G227 S228 G229 K230 T231 Y57 T61 Q64 G84 S85 G86 K87 T88
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5e7j, PDBe:5e7j, PDBj:5e7j
PDBsum5e7j
PubMed26598523
UniProtO00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

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