Structure of PDB 5e74 Chain A

Receptor sequence
>5e74A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVI
KKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
NMRKYFEKKWTDTFKV
3D structure
PDB5e74 The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
ChainA
Resolution1.783 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5KH A W1887 P1888 V1893 N1894 V1898 W32 P33 V38 N39 V43 MOAD: Kd=39uM
PDBbind-CN: -logKd/Ki=4.41,Kd=39uM
BindingDB: Kd=39000nM,IC50=27000nM
External links
PDB RCSB:5e74, PDBe:5e74, PDBj:5e74
PDBsum5e74
PubMed26982797
UniProtQ9UIF8|BAZ2B_HUMAN Bromodomain adjacent to zinc finger domain protein 2B (Gene Name=BAZ2B)

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