Structure of PDB 5e6c Chain A

Receptor sequence
>5e6cA (length=78) Species: 9606 (Homo sapiens) [Search protein sequence]
PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDK
IRRKNCPACRYRKCLQAGMNLEARKTKK
3D structure
PDB5e6c Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A C431 H432 Y433 K442 K446 R491 C14 H15 Y16 K25 K29 R74 PDBbind-CN: Kd=67.9uM
BS02 dna A G439 S440 R447 R470 R477 G22 S23 R30 R53 R60 PDBbind-CN: Kd=67.9uM
BS03 ZN A C421 C424 C438 C441 C4 C7 C21 C24
BS04 ZN A C457 C463 C473 C476 C40 C46 C56 C59
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5e6c, PDBe:5e6c, PDBj:5e6c
PDBsum5e6c
PubMed29626214
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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