Structure of PDB 5e3o Chain A

Receptor sequence

>5e3oA (length=91) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

SDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAE
VEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN

3D structure

PDB

5e3o DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.

Chain

Resolution

2.78 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	N84 T87 K90	N77 T80 K83	PDBbind-CN: Kd=28nM
BS02	dna	A	N73 Q74 T75 R85 R89	N66 Q67 T68 R78 R82	PDBbind-CN: Kd=28nM

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001216	DNA-binding transcription activator activity
GO:0001217	DNA-binding transcription repressor activity
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044374	sequence-specific DNA binding, bending

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006355	regulation of DNA-templated transcription
GO:0009314	response to radiation
GO:0032359	provirus excision
GO:0045892	negative regulation of DNA-templated transcription
GO:0045893	positive regulation of DNA-templated transcription
GO:0045911	positive regulation of DNA recombination
GO:0051276	chromosome organization

External links

PDB	RCSB:5e3o, PDBe:5e3o, PDBj:5e3o
PDBsum	5e3o
PubMed	26959646
UniProt	P0A6R3\|FIS_ECOLI DNA-binding protein Fis (Gene Name=fis)