Structure of PDB 5e3a Chain A

Receptor sequence
>5e3aA (length=725) Species: 9606 (Homo sapiens) [Search protein sequence]
ADTQYILPNDIGVSSLDSREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQ
TSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYS
NMGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELM
FSLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLF
KEVDGCGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDY
APILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWI
QDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAE
QLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQT
EGFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHA
LLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRCGETWDSKFST
IASSYEECRAESVGLYLSLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGL
LALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDA
RVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAP
PESFLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFS
ERFPEDGPELEEILTQLATADARFW
3D structure
PDB5e3a Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.4: dipeptidyl-peptidase III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E316 Y318 P387 A388 G389 I390 N391 N394 R399 H455 H568 R572 E315 Y317 P386 A387 G388 I389 N390 N393 R398 H454 H567 R571
BS02 ZN A H450 H455 E508 H449 H454 E507
BS03 MG A S101 N102 S384 S100 N101 S383
BS04 MG A G164 G167 G163 G166
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5e3a, PDBe:5e3a, PDBj:5e3a
PDBsum5e3a
PubMed27025154
UniProtQ9NY33|DPP3_HUMAN Dipeptidyl peptidase 3 (Gene Name=DPP3)

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