Structure of PDB 5e2a Chain A

Receptor sequence
>5e2aA (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
VPRGSTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSR
KFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDF
LVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHL
AEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICS
AGLSLLAEERQENLPDEIYHVYSFALR
3D structure
PDB5e2a Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.244: protein N-terminal methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W20 M30 L31 G32 W136 D177 D180 E213 I214 Y215 W24 M34 L35 G36 W140 D181 D184 E217 I218 Y219
BS02 SAH A W20 M30 G69 G71 R74 I75 D91 I92 T93 F96 G118 L119 Q135 W136 V137 H140 W24 M34 G73 G75 R78 I79 D95 I96 T97 F100 G122 L123 Q139 W140 V141 H144
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0071885 N-terminal protein N-methyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006480 N-terminal protein amino acid methylation
GO:0007051 spindle organization
GO:0007059 chromosome segregation
GO:0018012 N-terminal peptidyl-alanine trimethylation
GO:0018013 N-terminal peptidyl-glycine methylation
GO:0018016 N-terminal peptidyl-proline dimethylation
GO:0032259 methylation
GO:0035572 N-terminal peptidyl-serine dimethylation
GO:0035573 N-terminal peptidyl-serine trimethylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5e2a, PDBe:5e2a, PDBj:5e2a
PDBsum5e2a
PubMed26543161
UniProtQ9BV86|NTM1A_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Gene Name=NTMT1)

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