Structure of PDB 5e13 Chain A

Receptor sequence
>5e13A (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
MKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFA
NVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYA
QTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
3D structure
PDB5e13 Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin.
ChainA
Resolution1.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H15 K38
Catalytic site (residue number reindexed from 1) H16 K39
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5J9 A M0 K1 W7 R68 N70 A110 V128 H129 M1 K2 W8 R69 N71 A111 V129 H130 MOAD: Ki=57.8uM
PDBbind-CN: -logKd/Ki=4.24,Ki=57.8uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:5e13, PDBe:5e13, PDBj:5e13
PDBsum5e13
PubMed26551065
UniProtP10153|RNAS2_HUMAN Non-secretory ribonuclease (Gene Name=RNASE2)

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