Structure of PDB 5e0j Chain A

Receptor sequence
>5e0jA (length=174) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAI
HQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAV
RMGAIASMRIQGRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGN
DWVVCGVHAAATKSGNTVVCAVQA
3D structure
PDB5e0j Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies.
ChainA
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5LJ A H30 E54 M107 I109 Q110 R112 L132 C139 A158 A159 A160 V168 H31 E55 M108 I110 Q111 R113 L133 C140 A159 A160 A161 V169 PDBbind-CN: -logKd/Ki=5.21,IC50=6.1uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5e0j, PDBe:5e0j, PDBj:5e0j
PDBsum5e0j
PubMed27235842
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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