Structure of PDB 5e0h Chain A

Receptor sequence
>5e0hA (length=166) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAI
HQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAV
RMGAIASMRIQGRLVHGQSGMLLDLGTIPGDCGAPYVHKRGNDWVVCGVH
AAATKSGNTVVCAVQA
3D structure
PDB5e0h Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies.
ChainA
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5LH A H30 I109 Q110 T134 I135 P136 C139 H157 A158 A159 A160 H31 I110 Q111 T127 I128 P129 C132 H150 A151 A152 A153 PDBbind-CN: -logKd/Ki=5.62,IC50=2.4uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5e0h, PDBe:5e0h, PDBj:5e0h
PDBsum5e0h
PubMed27235842
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

[Back to BioLiP]