Structure of PDB 5dzd Chain A

Receptor sequence
>5dzdA (length=37) Species: 9606 (Homo sapiens) [Search protein sequence]
KPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKS
3D structure
PDB5dzd Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide
ChainA
Resolution1.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y495 V497 H499 R502 T504 T505 Y506 Y18 V20 H22 R25 T27 T28 Y29
BS02 peptide A R501 R502 R24 R25
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:5dzd, PDBe:5dzd, PDBj:5dzd
PDBsum5dzd
PubMed
UniProtQ96J02|ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog (Gene Name=ITCH)

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