Structure of PDB 5dzc Chain A

Receptor sequence
>5dzcA (length=816) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
GMRCNEKKKAIFSNSGEDTLMEDHLQLREKLSEDIEMIKASLKNNLVCST
LNDNEILTLSNYMQFFVFKGGDLVIKQGEKGSYFFIINSGKFDVYVNDKK
VKSMGKGSSFGEAALIHNTQRSATIMAETDGTLWGVQRSTFRATLKQLSN
RNFNENRSFIDSVSVFDMLTEAQKNMITNACVIQMFKPGETIVKQGDYGD
VLFILKEGKATVFINDKEIRVLNKGSYFGERALLYDEPRSATIIAKEPTA
CASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFRQFSAEQLNDLADTA
IVRDYPANYHILHKKSVKYLIVLEGKVELFLDDESIGILTRGKSFGDQYV
LNQKQKFRHTVKSLDVCKIALITESCLADCLGDNNIDASIDHNNKKSIIK
KMYIFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVE
VTKNGKRLRTLGKNDYFGERALLYDEPRTASIISKATSVECWFVDKSVFL
QIIQGPMLTHLEERIKMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQ
IRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVRTFKDSNCF
YFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRD
LKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKGYG
CTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQ
DSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPP
LVSKGETYAEDIDSWD
3D structure
PDB5dzc Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D657 K659 N662 D675 T692
Catalytic site (residue number reindexed from 1) D650 K652 N655 D668 T685
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A I540 G543 V548 A561 K563 V614 E618 L664 D675 I533 G536 V541 A554 K556 V607 E611 L657 D668
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
GO:0030553 cGMP binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5dzc, PDBe:5dzc, PDBj:5dzc
PDBsum5dzc
PubMed31239348
UniProtA5K0N4|KGP_PLAVS cGMP-dependent protein kinase (Gene Name=PKG)

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