Structure of PDB 5dxg Chain A

Receptor sequence
>5dxgA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHM
SNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5dxg Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E380 D538 L539 E542 I52 K56 L66 V70 E74 D221 L222 E225
BS02 EST A E353 F404 H524 L525 E47 F98 H207 L208 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:5dxg, PDBe:5dxg, PDBj:5dxg
PDBsum5dxg
PubMed26928945
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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