Structure of PDB 5dwe Chain A

Receptor sequence
>5dweA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAP
3D structure
PDB5dwe Predictive features of ligand-specific signaling through the estrogen receptor.
ChainA
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 V376 E380 D538 L539 E542 I52 K56 V70 E74 D222 L223 E226
BS02 5G5 A T347 A350 E353 F404 M421 I424 G521 L525 T41 A44 E47 F98 M115 I118 G205 L209 BindingDB: EC50=1.000000nM
External links
PDB RCSB:5dwe, PDBe:5dwe, PDBj:5dwe
PDBsum5dwe
PubMed27107013
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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