Structure of PDB 5dw2 Chain A

Receptor sequence
>5dw2A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5dw2 RVX-297- a novel BD2 selective inhibitor of BET bromodomains.
ChainA
Resolution1.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GD A P82 F83 V87 L92 N140 D144 I146 P41 F42 V46 L51 N99 D103 I105 MOAD: Kd=1.44uM
PDBbind-CN: -logKd/Ki=5.84,Kd=1.44uM
BindingDB: IC50=20nM
External links
PDB RCSB:5dw2, PDBe:5dw2, PDBj:5dw2
PDBsum5dw2
PubMed27282480
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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