Structure of PDB 5dw1 Chain A

Receptor sequence
>5dw1A (length=111) Species: 9606 (Homo sapiens) [Search protein sequence]
KLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPM
DLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQD
VFEFRYAKMPD
3D structure
PDB5dw1 RVX-297- a novel BD2 selective inhibitor of BET bromodomains.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GD A W370 P371 F372 V376 L383 N429 H433 W26 P27 F28 V32 L39 N85 H89 MOAD: ic50=0.08uM
PDBbind-CN: -logKd/Ki=7.10,IC50=0.08uM
External links
PDB RCSB:5dw1, PDBe:5dw1, PDBj:5dw1
PDBsum5dw1
PubMed27282480
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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