Structure of PDB 5dvc Chain A

Receptor sequence
>5dvcA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKFKHITPLKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNL
DLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKP
FGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI
QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKT
ETDMSLHPLLQEIYKDLY
3D structure
PDB5dvc Human PPARgamma ligand binding dmain complexed with SB1453 in a covalent bonded form
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 L311 V315 L318 K319 P467 L468 E471 K92 L102 V106 L109 K110 P258 L259 E262
BS02 T53 A I262 F264 I267 F282 G284 C285 Q286 R288 S289 I326 L330 I341 S342 E343 F363 L469 Y473 I57 F59 I62 F73 G75 C76 Q77 R79 S80 I117 L121 I132 S133 E134 F154 L260 Y264
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:5dvc, PDBe:5dvc, PDBj:5dvc
PDBsum5dvc
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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