Structure of PDB 5dv8 Chain A

Receptor sequence
>5dv8A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKFKHITPLSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVN
LDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRK
PFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIED
IQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKK
TETDMSLHPLLQEIYKDLY
3D structure
PDB5dv8 Human PPARgamma ligand binding dmain complexed with SB1451 in a covalent bonded form
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 L311 Q314 V315 L318 K319 L468 E471 K93 L103 Q106 V107 L110 K111 L260 E263
BS02 T51 A H266 F282 G284 C285 Q286 F287 R288 S289 I326 L330 I341 S342 F363 Y473 H61 F74 G76 C77 Q78 F79 R80 S81 I118 L122 I133 S134 F155 Y265
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:5dv8, PDBe:5dv8, PDBj:5dv8
PDBsum5dv8
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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