Structure of PDB 5dus Chain A

Receptor sequence
>5dusA (length=165) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search protein sequence]
MPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAG
AINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDAR
AKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRV
LVVVNSQDVYKSLTI
3D structure
PDB5dus Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Is an Efficient ADP-ribose Binding Module: CRYSTAL STRUCTURE AND BIOCHEMICAL STUDIES
ChainA
Resolution1.432 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR A D20 A21 A36 N38 G44 G46 I47 L124 S126 G128 I129 F130 N154 D21 A22 A37 N39 G45 G47 I48 L125 S127 G129 I130 F131 N155 MOAD: Kd=2.95uM
PDBbind-CN: -logKd/Ki=5.53,Kd=2.95uM
External links
PDB RCSB:5dus, PDBe:5dus, PDBj:5dus
PDBsum5dus
PubMed26740631
UniProtK9N638|R1A_MERS1 Replicase polyprotein 1a (Gene Name=1a)

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