Structure of PDB 5duh Chain A

Receptor sequence
>5duhA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5duh Predictive features of ligand-specific signaling through the estrogen receptor.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 L372 D538 E542 I54 L68 D226 E230
BS02 5FT A M343 L346 T347 A350 E353 L384 L387 L391 F404 G420 M421 I424 L428 G521 H524 L525 M39 L42 T43 A46 E49 L80 L83 L87 F100 G116 M117 I120 L124 G209 H212 L213 BindingDB: EC50=12nM
External links
PDB RCSB:5duh, PDBe:5duh, PDBj:5duh
PDBsum5duh
PubMed27107013
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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