Structure of PDB 5dug Chain A

Receptor sequence
>5dugA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5dug Predictive features of ligand-specific signaling through the estrogen receptor.
ChainA
Resolution2.252 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 V376 E380 E542 I53 K57 V71 E75 E228
BS02 5FV A L346 T347 A350 E353 L384 F404 M421 I424 F425 G521 H524 L525 L41 T42 A45 E48 L79 F99 M116 I119 F120 G207 H210 L211 BindingDB: EC50=0.14nM
External links
PDB RCSB:5dug, PDBe:5dug, PDBj:5dug
PDBsum5dug
PubMed27107013
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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