Structure of PDB 5du6 Chain A

Receptor sequence
>5du6A (length=242) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
HMIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVL
TGQGTAFCAGADLSGFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAG
LQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAML
LSAEKLTAEIALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLND
DGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKFQGA
3D structure
PDB5du6 THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.
ChainA
Resolution2.61 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A60 P72 I76 A100 Q103 P122 T123 L128 L130 D131 P210 W220
Catalytic site (residue number reindexed from 1) A61 P71 I75 A99 Q102 P121 T122 L127 L129 D130 P209 W219
Enzyme Commision number 4.2.1.17: enoyl-CoA hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G59 A L75 D83 D131 W133 A208 K213 F216 L74 D82 D130 W132 A207 K212 F215 PDBbind-CN: -logKd/Ki=5.02,Kd=9.6uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5du6, PDBe:5du6, PDBj:5du6
PDBsum5du6
PubMed27571973
UniProtP9WNP1|ECHA6_MYCTU Probable enoyl-CoA hydratase EchA6 (Gene Name=echA6)

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