Structure of PDB 5ds3 Chain A

Receptor sequence
>5ds3A (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
SKLPKPVQDLIKMIFGSGSGSGGDPIDVNYEKLKTDIKVVDRDSEEAEII
RKYVKNTHHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTT
NFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIG
LILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGV
DVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK
3D structure
PDB5ds3 PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S904 Y907 E988
Catalytic site (residue number reindexed from 1) S137 Y140 E221
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 09L A H862 G863 R878 Y889 G894 I895 Y896 F897 K903 S904 Y907 E988 H95 G96 R111 Y122 G127 I128 Y129 F130 K136 S137 Y140 E221 BindingDB: IC50=6.0nM,EC50=3.6nM,Kd=0.240000nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5ds3, PDBe:5ds3, PDBj:5ds3
PDBsum5ds3
PubMed26626480
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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