Structure of PDB 5drb Chain A

Receptor sequence
>5drbA (length=273) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLT
KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGT
LKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFIT
GPTGSVKIGDLGLATLKRASFAKAVIGTPEFMAPEMYEEKYDESVDVYAF
GMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEG
CIRQNKDERYSIKDLLNHAFFQE
3D structure
PDB5drb Small-molecule WNK inhibition regulates cardiovascular and renal function.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D349 K351 D353 N354 D368 K375 T386
Catalytic site (residue number reindexed from 1) D141 K143 D145 N146 D160 K167 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5FJ A G228 V235 A248 C250 L272 F283 T301 M304 F356 D368 L369 G370 G20 V27 A40 C42 L64 F75 T93 M96 F148 D160 L161 G162 MOAD: Kd=3.71nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5drb, PDBe:5drb, PDBj:5drb
PDBsum5drb
PubMed27595330
UniProtQ9JIH7|WNK1_RAT Serine/threonine-protein kinase WNK1 (Gene Name=Wnk1)

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