Structure of PDB 5dqi Chain A

Receptor sequence

>5dqiA (length=424) Species: 9606 (Homo sapiens)

ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERET
GFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSL
GGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHD
PVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRND
NDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 5dqi Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 I48 R61 S62 K86 K311 R313 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351	Q37 Y38 W41 I47 R60 S61 K85 K303 R305 P308 K309 T310 G312 C313 S314 K315 N316 P318 R343
BS02	dna	A	R111 A112 S113 I114 S257 G259 G260 K261 L262 R377 R382 C384	R110 A111 S112 I113 S249 G251 G252 K253 L254 R369 R374 C376
BS03	DCP	A	D13 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D12 D14 C15 F16 F17 Y51 R54 R60 D114 K223
BS04	CA	A	D13 M14 D115	D12 M13 D114
BS05	CA	A	D13 D115 E116	D12 D114 E115

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:5dqi, PDBe:5dqi, PDBj:5dqi
• PDBsum: 5dqi
• PubMed: 27574558
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)