Structure of PDB 5dq8 Chain A

Receptor sequence
>5dq8A (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
GLGTARLQLVEFSAFVEPQRHLFVHISQLESVDVRQIYDKFPEKKGGLRE
LYDRGPPHAFFLVKFWADLNWGFYGVSSQYESLEHMTLTCSSKVCSFGKQ
VVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVL
ENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVR
3D structure
PDB5dq8 Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
ChainA
Resolution2.305 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLF A F233 S345 V347 K357 M379 C380 L383 I408 F12 S92 V94 K104 M126 C127 L130 I155 MOAD: Kd=73uM
PDBbind-CN: -logKd/Ki=4.14,Kd=73uM
External links
PDB RCSB:5dq8, PDBe:5dq8, PDBj:5dq8
PDBsum5dq8
PubMed26592798
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

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