Structure of PDB 5dp9 Chain A

Receptor sequence
>5dp9A (length=181) Species: 39054 (Enterovirus A71) [Search protein sequence]
MGPSLDFALSLLRRNVRQVQTDQGHFTMLGVRDRLAVLPRHSQPGKTIWI
EHKLVNILDAVELVDEQGVNLELTLITLDTNEKFRDITKFIPENISTASD
ATLVINTEHMPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKAGQCGG
VVTSVGKVIGIHIGGNGRQGFCAGLKRSYFA
3D structure
PDB5dp9 Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H41 E72 G146 C148
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5EX A H40 E71 L125 N126 L127 S128 T142 K143 A144 C147 H161 I162 G163 G164 H41 E72 L126 N127 L128 S129 T143 K144 A145 C148 H162 I163 G164 G165 PDBbind-CN: -logKd/Ki=6.08,IC50=0.84uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5dp9, PDBe:5dp9, PDBj:5dp9
PDBsum5dp9
PubMed26987809
UniProtA9XG43

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