Structure of PDB 5dp6 Chain A

Receptor sequence

>5dp6A (length=178) Species: 39054 (Enterovirus A71)

SLDFALSLLRRNVRQVQTDQGHFTMLGVRDRLAVLPRHSQPGKTIWIEHK
LVNILDAVELVDEQGVNLELTLITLDTNEKFRDITKFIPENISTASDATL
VINTEHMPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKAGQCGGVVT
SVGKVIGIHIGGNGRQGFCAGLKRSYFA

3D structure

• PDB: 5dp6 Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
• Chain: A
• Resolution: 3.01 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H40 E71 G145 C147
• Catalytic site (residue number reindexed from 1): H38 E69 G143 C145
• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.29: picornain 2A.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	5EB	A	H40 L127 S128 T142 K143 G145 C147 I162 G164	H38 L125 S126 T140 K141 G143 C145 I160 G162	PDBbind-CN: -logKd/Ki=4.83,IC50=14.71uM

Gene Ontology

Molecular Function

• GO:0004197 cysteine-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:5dp6, PDBe:5dp6, PDBj:5dp6
• PDBsum: 5dp6
• PubMed: 26987809
• UniProt: A9XG43