Structure of PDB 5dmz Chain A

Receptor sequence
>5dmzA (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]
NFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGS
KLVYVHHLLGEGAFAQVYEATQQKFVLKVQKPANPWEFYIGTQLMERLKP
SMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGL
VISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLA
LIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAA
TVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHH
LPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRS
3D structure
PDB5dmz Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G794 E795 G796 F798 A799 V801 K821 Y869 T873 I924 I945 D946 G60 E61 G62 F64 A65 V67 K78 Y126 T130 I181 I202 D203
BS02 MG A N922 D946 N179 D203
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007094 mitotic spindle assembly checkpoint signaling

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5dmz, PDBe:5dmz, PDBj:5dmz
PDBsum5dmz
PubMed26658523
UniProtO43683|BUB1_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 (Gene Name=BUB1)

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