Structure of PDB 5dh3 Chain A

Receptor sequence
>5dh3A (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
LTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEII
KEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL
IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVA
GQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK
PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRAT
ATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQR
3D structure
PDB5dh3 Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
ChainA
Resolution2.468 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 K148 G150 N151 D164 D173 T184
Catalytic site (residue number reindexed from 1) D128 K130 G132 N133 D146 D155 T166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5BS A L33 V41 E100 Y101 C102 G103 G105 D109 L153 L15 V23 E82 Y83 C84 G85 G87 D91 L135 MOAD: ic50=38.1nM
PDBbind-CN: -logKd/Ki=7.42,IC50=38.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5dh3, PDBe:5dh3, PDBj:5dh3
PDBsum5dh3
PubMed27535619
UniProtQ13188|STK3_HUMAN Serine/threonine-protein kinase 3 (Gene Name=STK3)

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