Structure of PDB 5dgj Chain A

Receptor sequence
>5dgjA (length=168) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HHAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIA
IHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLA
VRMGAIASMRIQGRLVHGQSGMLLTGANAKGMDLGDCGAPYVHKRGNDWV
VCGVHAAATNTVVCAVQA
3D structure
PDB5dgj Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease.
ChainA
Resolution1.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V64 A H30 E54 I109 Q110 C139 A158 A159 A160 H32 E56 I111 Q112 C137 A156 A157 A158 PDBbind-CN: -logKd/Ki=4.73,IC50=18.5uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5dgj, PDBe:5dgj, PDBj:5dgj
PDBsum5dgj
PubMed26823007
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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