Structure of PDB 5dfc Chain A

Receptor sequence

>5dfcA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]

LSEQLKHCNGILKELLSKKHAAYAFPFYKPVDASALGLHDYHDIIKHPMD
LSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV
FEFRYAKMP

3D structure

PDB

5dfc New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.

Chain

Resolution

1.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	EAM	A	P371 L383 N429 V435 M438	P26 L38 N84 V90 M93	BindingDB: IC50=32.5nM,Ki=74nM,Kd=100nM

External links

PDB	RCSB:5dfc, PDBe:5dfc, PDBj:5dfc
PDBsum	5dfc
PubMed	26367539
UniProt	P25440\|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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