Structure of PDB 5df6 Chain A

Receptor sequence
>5df6A (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN
CADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRT
GDDKGESKSKVTHVMIRCQKYDVGGGERFDSLTDLVEHYKKNPMVETLGT
VLQLKQPLNTTR
3D structure
PDB5df6 Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R32 K35 S36 T42 T52 H53 Q87 L88 K89 E90 K91 R29 K32 S33 T39 T49 H50 Q84 L85 K86 E87 K88
BS02 peptide A K120 R138 Q141 S142 V148 T168 H169 M171 M202 V203 T205 K117 R135 Q138 S139 V145 T162 H163 M165 M194 V195 T197
External links
PDB RCSB:5df6, PDBe:5df6, PDBj:5df6
PDBsum5df6
PubMed26527736
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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