Structure of PDB 5ddf Chain A

Receptor sequence
>5ddfA (length=464) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINS
SAIKLQLTAQSQVQ
3D structure
PDB5ddf Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.
ChainA
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5A1 A S155 S178 E179 D180 H181 Y276 M278 N282 Y319 M322 Y323 Q586 S134 S157 E158 D159 H160 Y255 M257 N261 Y298 M301 Y302 Q464 MOAD: ic50=674nM
PDBbind-CN: -logKd/Ki=6.17,IC50=674nM
BindingDB: IC50=674nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5ddf, PDBe:5ddf, PDBj:5ddf
PDBsum5ddf
PubMed26288158
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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