Structure of PDB 5dde Chain A

Receptor sequence
>5ddeA (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINS
SAIKLQLTAQSQVQMK
3D structure
PDB5dde Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5A0 A S155 H181 F238 C241 Y276 M278 N282 Y319 M322 Y323 S134 H160 F217 C220 Y255 M257 N261 Y298 M301 Y302 MOAD: ic50=65nM
PDBbind-CN: -logKd/Ki=7.19,IC50=65nM
BindingDB: IC50=65nM
BS02 5A0 A S155 L177 F238 C241 Y276 M278 N282 Y319 M322 Y323 S134 L156 F217 C220 Y255 M257 N261 Y298 M301 Y302 MOAD: ic50=65nM
PDBbind-CN: -logKd/Ki=7.19,IC50=65nM
BindingDB: IC50=65nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5dde, PDBe:5dde, PDBj:5dde
PDBsum5dde
PubMed26288158
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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