Structure of PDB 5ddc Chain A

Receptor sequence
>5ddcA (length=465) Species: 9606 (Homo sapiens) [Search protein sequence]
LKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNR
VGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVS
DVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRD
VHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLY
LKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGH
LERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYM
YLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVI
PNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHV
GWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINSS
AIKLQLTAQSQVQMK
3D structure
PDB5ddc Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 59V A S155 L177 S178 H181 F238 C241 Y276 M278 N282 Y319 M322 Y323 S133 L155 S156 H159 F216 C219 Y254 M256 N260 Y297 M300 Y301 MOAD: ic50=92nM
PDBbind-CN: -logKd/Ki=7.04,IC50=92nM
BindingDB: IC50=92nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5ddc, PDBe:5ddc, PDBj:5ddc
PDBsum5ddc
PubMed26288158
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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