Structure of PDB 5ddb Chain A

Receptor sequence
>5ddbA (length=463) Species: 9606 (Homo sapiens) [Search protein sequence]
LKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNR
VGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVS
DVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRD
VHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLY
LKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGH
LERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYM
YLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVI
PNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHV
GWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINSS
AIKLQLTAQSQVQ
3D structure
PDB5ddb Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 59Q A S155 L177 S178 H181 C241 Y276 M278 N282 Y319 M322 Y323 S133 L155 S156 H159 C219 Y254 M256 N260 Y297 M300 Y301 MOAD: ic50=82nM
PDBbind-CN: -logKd/Ki=7.09,IC50=82nM
BindingDB: IC50=82nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5ddb, PDBe:5ddb, PDBj:5ddb
PDBsum5ddb
PubMed26288158
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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