Structure of PDB 5dd9 Chain A

Receptor sequence
>5dd9A (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINS
SAIKLQLTAQSQVQMK
3D structure
PDB5dd9 Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 59K A S155 L177 S178 H181 F238 C241 Y276 M278 N282 Y319 M322 Y323 K588 S134 L156 S157 H160 F217 C220 Y255 M257 N261 Y298 M301 Y302 K466 MOAD: ic50=779nM
PDBbind-CN: -logKd/Ki=6.11,IC50=779nM
BindingDB: IC50=779nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5dd9, PDBe:5dd9, PDBj:5dd9
PDBsum5dd9
PubMed26288158
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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