Structure of PDB 5db0 Chain A

Receptor sequence
>5db0A (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINS
SAIKLQLTAQSQVQMK
3D structure
PDB5db0 Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 58P A S155 L177 S178 H181 F238 Y276 M278 Y319 M322 Y323 W341 E363 E366 S134 L156 S157 H160 F217 Y255 M257 Y298 M301 Y302 W320 E342 E345 MOAD: ic50=46nM
PDBbind-CN: -logKd/Ki=7.43,IC50=37nM
BS02 6E6 A S155 L177 S178 H181 F238 Y276 M278 Y319 M322 Y323 W341 E363 E366 S134 L156 S157 H160 F217 Y255 M257 Y298 M301 Y302 W320 E342 E345 MOAD: ic50=42nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5db0, PDBe:5db0, PDBj:5db0
PDBsum5db0
PubMed26744767
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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