Structure of PDB 5d9l Chain A

Receptor sequence
>5d9lA (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
EIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYA
MKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILD
FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPEN
ILLDEEGHIKLTDFGLSKEGTVEYMAPEVVNRRGHTQSADWWSFGVLMFE
MLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANR
LGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP
3D structure
PDB5d9l Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D193 K195 E197 N198 D211 T231
Catalytic site (residue number reindexed from 1) D145 K147 E149 N150 D163 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 583 A V82 A98 K100 L147 F149 L150 L200 D211 F212 V34 A50 K52 L99 F101 L102 L152 D163 F164 MOAD: ic50=0.024uM
PDBbind-CN: -logKd/Ki=7.62,IC50=0.024uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5d9l, PDBe:5d9l, PDBj:5d9l
PDBsum5d9l
PubMed26270416
UniProtP51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (Gene Name=RPS6KA3)

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