Structure of PDB 5d9k Chain A

Receptor sequence
>5d9kA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRD
RVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK
EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTD
FGLSKCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDR
KETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKR
HSFFSTIDWNKLYRREIHPPFKPATFYFDP
3D structure
PDB5d9k Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
ChainA
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D193 K195 E197 N198 D211 T231
Catalytic site (residue number reindexed from 1) D132 K134 E136 N137 D150 T158
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 584 A G75 F79 V82 A98 V131 D148 F149 L150 L200 D211 F212 G14 F18 V21 A37 V70 D87 F88 L89 L139 D150 F151 PDBbind-CN: -logKd/Ki=8.40,IC50=0.004uM
BindingDB: IC50=4.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5d9k, PDBe:5d9k, PDBj:5d9k
PDBsum5d9k
PubMed26270416
UniProtP51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (Gene Name=RPS6KA3)

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