Structure of PDB 5d9j Chain A

Receptor sequence

>5d9jA (length=179) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1)))

MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD
GGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKSLPDLYDYKENRFIE
IGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRA
RIKTRLFTIRQEMASRSLWDSFRQSERAA

3D structure

• PDB: 5d9j Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.
• Chain: A
• Resolution: 1.85 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	H41 D89 E100 I101	H41 D89 E100 I101
BS02	MN	A	E61 D89	E61 D89
BS03	0N8	A	A37 I38 H41 E61 D89 E100 K115	A37 I38 H41 E61 D89 E100 K115	MOAD: Kd=22nM

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:5d9j, PDBe:5d9j, PDBj:5d9j
• PDBsum: 5d9j
• PubMed: 26976575
• UniProt: C3W5S0