Structure of PDB 5d7q Chain A

Receptor sequence
>5d7qA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGL
YDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMR
LLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHE
YPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLK
VDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGL
GGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASID
A
3D structure
PDB5d7q Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.
ChainA
Resolution2.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P41 D42 F43 R44 N115 D117 H134
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C195 C200 C221 C224 C142 C147 C168 C171
BS02 AR6 A G84 A85 G86 T89 D95 F96 R97 Q167 H187 F235 G261 T262 S263 V266 N286 K287 E288 E323 C324 G31 A32 G33 T36 D42 F43 R44 Q114 H134 F182 G208 T209 S210 V213 N233 K234 E235 E270 C271
BS03 4I5 A P94 F96 Q167 N168 I169 D170 I232 F234 P41 F43 Q114 N115 I116 D117 I179 F181 MOAD: ic50=2.8uM
BindingDB: IC50=2770nM
BS04 4I5 A I93 F119 L138 Y139 G141 D170 I40 F66 L85 Y86 G88 D117 MOAD: ic50=2.8uM
BindingDB: IC50=2770nM
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5d7q, PDBe:5d7q, PDBj:5d7q
PDBsum5d7q
PubMed26625292
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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