Structure of PDB 5d7c Chain A

Receptor sequence
>5d7cA (length=192) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
AGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYAN
QIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTSSVVNALSQDL
EVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETT
VYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYE
3D structure
PDB5d7c Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 57W A S55 E58 V79 D81 R84 G85 I86 P87 I102 R144 T173 I175 S40 E43 V64 D66 R69 G70 I71 P72 I87 R106 T135 I137 MOAD: ic50=0.14uM
PDBbind-CN: -logKd/Ki=6.85,IC50=0.14uM
BindingDB: IC50=140nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5d7c, PDBe:5d7c, PDBj:5d7c
PDBsum5d7c
PubMed26460684
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB)

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