Structure of PDB 5d3s Chain A

Receptor sequence
>5d3sA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB5d3s 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 579 A W81 P82 Q85 V87 L92 Y139 N140 I146 W39 P40 Q43 V45 L50 Y97 N98 I104 MOAD: Kd=1.3uM
PDBbind-CN: -logKd/Ki=5.89,Kd=1.3uM
BindingDB: Kd=1300nM
BS02 BU3 A W81 I146 W39 I104
External links
PDB RCSB:5d3s, PDBe:5d3s, PDBj:5d3s
PDBsum5d3s
PubMed26731611
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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