Structure of PDB 5d3l Chain A

Receptor sequence
>5d3lA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5d3l 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 57F A W81 P82 F83 V87 L92 Y97 Y139 N140 I146 W40 P41 F42 V46 L51 Y56 Y98 N99 I105 MOAD: Kd=0.88uM
PDBbind-CN: -logKd/Ki=6.06,Kd=0.88uM
BindingDB: Kd=880nM
External links
PDB RCSB:5d3l, PDBe:5d3l, PDBj:5d3l
PDBsum5d3l
PubMed26731611
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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