Structure of PDB 5d3j Chain A

Receptor sequence
>5d3jA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5d3j 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L33 A W81 P82 V87 K91 L92 N140 W39 P40 V45 K49 L50 N98 MOAD: Kd=5.7uM
PDBbind-CN: -logKd/Ki=5.24,Kd=5.7uM
BindingDB: Kd=5700nM
External links
PDB RCSB:5d3j, PDBe:5d3j, PDBj:5d3j
PDBsum5d3j
PubMed26731611
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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