Structure of PDB 5d39 Chain A

Receptor sequence
>5d39A (length=489) Species: 9606 (Homo sapiens) [Search protein sequence]
QEELKFKTGLRRLQHRVGEIHLLREALALAMLLQETTGELEAAKALVLKR
IQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELE
PKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
FLPAKPPLVRADMVTEKQARELESTGEIINNTVPLENSIPGNCCSALFKN
LLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVV
IVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAE
VGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGF
TFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLR
FSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQL
KNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVE
3D structure
PDB5d39 Structural basis for DNA recognition by STAT6
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R370 S378 V379 V414 H415 N417 R208 S216 V217 V252 H253 N255 PDBbind-CN: Kd=1.8uM
BS02 dna A K288 H415 K138 H253 PDBbind-CN: Kd=1.8uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5d39, PDBe:5d39, PDBj:5d39
PDBsum5d39
PubMed27803324
UniProtP42226|STAT6_HUMAN Signal transducer and activator of transcription 6 (Gene Name=STAT6)

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