Structure of PDB 5d1t Chain A

Receptor sequence
>5d1tA (length=488) Species: 1392 (Bacillus anthracis) [Search protein sequence]
RYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEK
ELLKRIQIDSSDFLSTEEKEFLKKLQIDILSEKEKEFLKKLKLDIQPYDI
NQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLY
ENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDI
NERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQS
EKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVH
NRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPN
IAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEF
GHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFA
EAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
3D structure
PDB5d1t Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H398 E399 H402 Y440 E447
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H686 H690 E735 H398 H402 E447
BS02 56R A D328 S655 K656 G657 L677 H686 E687 H690 Y728 E739 D62 S367 K368 G369 L389 H398 E399 H402 Y440 E451 MOAD: ic50=1.7uM
PDBbind-CN: -logKd/Ki=5.77,IC50=1.7uM
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:5d1t, PDBe:5d1t, PDBj:5d1t
PDBsum5d1t
PubMed26492514
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

[Back to BioLiP]