Structure of PDB 5d1s Chain A

Receptor sequence
>5d1sA (length=507) Species: 1392 (Bacillus anthracis) [Search protein sequence]
LSRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQE
EKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRINPLS
EKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNI
DALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFN
EFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKL
ILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQE
WNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVT
NYLVDGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLH
GPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFK
EEGSNLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQ
IKFIINS
3D structure
PDB5d1s Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H417 E418 H421 Y459 E466
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 56Q A S655 K656 G657 V675 L677 H686 E687 H690 Y728 E735 E739 S386 K387 G388 V406 L408 H417 E418 H421 Y459 E466 E470 MOAD: ic50=9.6uM
PDBbind-CN: -logKd/Ki=5.02,IC50=9.6uM
BindingDB: IC50=37000nM
BS02 ZN A H686 H690 E735 H417 H421 E466
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:5d1s, PDBe:5d1s, PDBj:5d1s
PDBsum5d1s
PubMed26492514
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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