Structure of PDB 5d0c Chain A

Receptor sequence
>5d0cA (length=129) Species: 9606 (Homo sapiens) [Search protein sequence]
LVPRGSNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPV
DAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCY
IYNKPGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB5d0c Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation
ChainA
Resolution1.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E0B A W81 P82 F83 L92 L94 N140 M149 W44 P45 F46 L55 L57 N103 M112 MOAD: Kd=2.34uM
PDBbind-CN: -logKd/Ki=5.63,Kd=2.340uM
BindingDB: Kd=2340nM,IC50=3180nM
External links
PDB RCSB:5d0c, PDBe:5d0c, PDBj:5d0c
PDBsum5d0c
PubMed26731490
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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